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Image Search Results
Journal: PLoS Genetics
Article Title: Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development
doi: 10.1371/journal.pgen.1003025
Figure Lengend Snippet: Cytogenetic analysis of a cleavage stage embryo from a Robertsonian translocation carrier- 46,XY,t(13;15)(q21.3;q11.2). Microarray-CGH revealed monosomy 13, presumably resulting from a meiotic error due to problems processing the rearranged chromosomes. An additional aneuploidy unrelated to the Robertsonian translocation (monosomy for chromosome 1) was also detected. The two monosomies are indicated by the altered ratio of fluorescence related to the test (embryo) and reference (46,XY) DNA samples. All of the probes corresponding to chromosomes 1 and 13 have test/reference ratios less than 0.3.
Article Snippet: Amplified sample and reference DNAs were labelled with Cy3 and Cy5 respectively and then hybridized to the probes of a bacterial
Techniques: Translocation Assay, Microarray, Fluorescence